Description

L-Asparagine-Amide-15N Monohydrate is a stable isotope-labeled derivative of the amino acid L-asparagine, where the amide nitrogen is enriched with the 15N isotope. This compound is essential for advanced research in metabolism, protein dynamics, and structural biology, providing a critical tool for precise tracking and quantification using techniques like NMR and mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers developing sophisticated analytical methods and tracer studies.

Application

• Metabolic Pathway Tracing: Used as a 15N-labeled tracer in NMR and MS-based studies to investigate amino acid and nitrogen metabolism in biological systems.
• Protein & Peptide Research: Serves as a building block for the synthesis of isotopically labeled peptides and proteins for structural determination and dynamics studies.
• Biomedical Diagnostics: Employed as an internal standard in quantitative mass spectrometry for the accurate measurement of asparagine and related metabolites in clinical and research samples.
• Nutrient Uptake Studies: Applied in plant and microbial physiology research to study nitrogen assimilation and amino acid transport mechanisms.
• Pharmaceutical Development: Utilized in drug metabolism and pharmacokinetics (DMPK) studies to trace the metabolic fate of drug candidates containing asparagine moieties.
• Isotope Dilution Analysis: A key component in high-precision analytical methods for quantifying asparagine levels in complex matrices like food, supplements, and biological fluids.

Basic Information

Product Name	L-Asparagine-Amide-15N Monohydrate
CAS No.	287484-30-4
Molecular Formula	C₄H₈¹⁵N₂O₃ • H₂O
Molecular Weight	151.12 g/mol (for ¹⁵N labeled form)
Synonyms	(2S)-2-Amino-3-carbamoylpropanoic acid-amide-15N monohydrate; L-Asparagine-amide-15N hydrate; H-Asp-NH₂-15N•H₂O; (S)-2-Amino-3-carbamoylpropanoic acid-amide-15N monohydrate; L-2-Aminosuccinamic acid-amide-15N monohydrate; 15N-L-Asparagine amide monohydrate; Isotope-labeled L-asparagine amide
EINECS	Contact for details

Quality Control

Our L-Asparagine-Amide-15N Monohydrate is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 15N), chemical purity by HPLC, chiral purity, and residual solvent content. We adhere to relevant guidelines for the production of stable isotope-labeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment (Atom % 15N)	≥98%
Chiral Purity (HPLC)	≥99.0% L-Isomer
Water Content (KF)	7.0% - 10.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.