Description

3-Hydroxybutyric-2,4-13C2 Acid, Sodium Salt is a stable, isotopically labeled sodium salt of β-hydroxybutyrate, a key metabolic intermediate. This compound is specifically enriched with carbon-13 at the 2 and 4 positions, making it an essential tool for advanced metabolic research and analytical method development. It is primarily used by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for tracer studies, quantitative NMR, and mass spectrometry applications.

Application

• Metabolic Tracer Studies: Used in in vitro and in vivo research to trace ketone body metabolism, fatty acid synthesis, and energy pathways.
• Quantitative NMR (qNMR) Standard: Serves as a high-purity internal standard for the accurate quantification of metabolites in complex biological matrices.
• Mass Spectrometry (MS) Internal Standard: Provides a stable isotope-labeled reference for LC-MS/MS and GC-MS analysis of β-hydroxybutyrate and related compounds in clinical and research settings.
• Diagnostic Kit Manufacturing: Incorporated as a critical calibrator or component in kits for measuring ketone bodies in blood, serum, or urine.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate the pathways of compounds targeting metabolic disorders.
• Nutritional Science Research: Used to study ketogenic diets, starvation physiology, and the metabolic effects of exogenous ketone supplements.

Basic Information

Product Name	3-Hydroxybutyric-2,4-13C2 Acid, Sodium Salt
CAS No.	287389-35-9
Molecular Formula	C413C2H7NaO3
Molecular Weight	~130.08 g/mol (based on 13C enrichment)
Synonyms	Sodium 3-Hydroxybutyrate-2,4-13C2; Sodium β-Hydroxybutyrate-2,4-13C2; BHB-13C2 Sodium Salt; 3-Hydroxybutanoic-2,4-13C2 Acid Sodium Salt; (RS)-3-Hydroxybutyric-2,4-13C2 Acid Sodium Salt; Ketone Body Tracer 13C2; Sodium DL-3-Hydroxybutyrate-2,4-13C2
EINECS	Contact for details

Quality Control

Every batch of our isotopically labeled materials is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and MS to confirm 13C enrichment at the specified positions and chemical identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting assay, isotopic enrichment, and impurity profiles. Our quality commitment ensures reliability for your most sensitive research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and labeling pattern
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99 atom % 13C at positions 2 & 4
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.