Description

N'-([3,5-Bis(Trifluoromethyl)Benzoyl]Oxy)-2-Chloroethanimidamide is a specialized organic intermediate featuring a reactive chloroethanimidamide group linked to a lipophilic, electron-deficient bis(trifluoromethyl)benzoyl moiety. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of trifluoromethyl groups is crucial for modulating bioactivity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or oncology, where the trifluoromethyl group enhances membrane permeability and binding affinity.
• Agrochemical Active Ingredient Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the stability and bioactivity imparted by the fluorinated aromatic system.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and coatings with unique chemical resistance, low surface energy, or specific optical properties.
• Chemical Biology Probe Development: Employed to create labeled compounds or activity-based probes for studying enzyme mechanisms and protein function in biological systems.
• Ligand and Catalyst Preparation: Utilized for constructing sophisticated ligands for transition metal catalysis or organocatalysts, taking advantage of the electron-withdrawing character of the benzoyl group.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client-specific research and development projects.

Basic Information

Product Name	N'-([3,5-Bis(Trifluoromethyl)Benzoyl]Oxy)-2-Chloroethanimidamide
CAS No.	287198-13-4
Molecular Formula	C12H7ClF6N2O2
Molecular Weight	360.64 g/mol
Synonyms	2-Chloro-N'-[3,5-bis(trifluoromethyl)benzoyl]oxy]ethanimidamide; 2-Chloro-N'-([3,5-bis(trifluoromethyl)benzoyl]oxy)acetimidamide; 2-Chloro-N-((3,5-bis(trifluoromethyl)benzoyl)oxy)acetimidamide; N-([3,5-Bis(trifluoromethyl)benzoyl]oxy)-2-chloroacetimidamide; 287198-13-4; Acetimidamide, 2-chloro-N-[[3,5-bis(trifluoromethyl)benzoyl]oxy]-
EINECS	Contact for details

Quality Control

Our N'-([3,5-Bis(Trifluoromethyl)Benzoyl]Oxy)-2-Chloroethanimidamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Standard testing includes identity confirmation (IR, NMR), purity assay (HPLC), and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.