Description

D-[Ul-13C6]Mannitol is a stable isotope-labeled analog of the sugar alcohol mannitol, where all six carbon atoms are uniformly enriched with the carbon-13 isotope. This high-purity labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) engaged in mass spectrometry-based metabolomics, pharmacokinetic studies, and stable isotope-resolved flux analysis.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Used as a reference standard in LC-MS and GC-MS for the accurate quantification of endogenous mannitol and related metabolites in complex biological matrices.
• Metabolic Flux Analysis (MFA): Enables the tracing of carbon flow through metabolic pathways in cell cultures, tissues, or microorganisms to study central carbon metabolism.
• Pharmacokinetic and Drug Metabolism Studies: Serves as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) of mannitol or related compounds in preclinical research.
• NMR Spectroscopy: Acts as a carbon-13 enriched substrate for Nuclear Magnetic Resonance (NMR) studies to elucidate metabolic structures and dynamics.
• Clinical Research Diagnostics: Potential use as a labeled probe in specialized diagnostic assays for intestinal permeability or renal function testing in research settings.
• Biochemical Research Reagent: Employed in enzymatic assays and in vitro studies investigating sugar alcohol metabolism and related enzymatic activities.

Basic Information

Item	Detail
Product Name	D-[Ul-13C6]Mannitol
CAS No.	287112-34-9
Molecular Formula	13C6H14O6
Molecular Weight	188.12 (for 13C6)
Synonyms	D-Mannitol-13C6; Mannitol (U-13C6); (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol-13C6; 1,2,3,4,5,6-Hexanehexol-13C6; Mannitol U-13C6; [U-13C]Mannitol; Isotopic Mannitol Standard
EINECS	Contact for details

Quality Control

Every batch of D-[Ul-13C6]Mannitol is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on isotopic enrichment, chemical purity, and specific analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.