Description

Mevalonic-1,2-13C2 Lactone is a stable, isotopically labeled derivative of mevalonic acid lactone, specifically enriched with carbon-13 at the 1 and 2 positions. This compound is a critical tool for advanced metabolic pathway tracing and quantitative analysis in biochemical research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who require precise internal standards for mass spectrometry or are investigating the mevalonate pathway, cholesterol biosynthesis, and isoprenoid metabolism.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of mevalonic acid and related metabolites in complex biological matrices.
• Metabolic Flux Analysis (MFA): Used as a tracer to study carbon flow and regulation within the mevalonate and terpenoid biosynthesis pathways.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables precise tracking of drug candidates that interact with or are metabolized through the mevalonate pathway.
• Biochemical Research: Essential for in vitro and in vivo studies focused on enzyme kinetics (e.g., HMG-CoA reductase), pathway regulation, and lipid metabolism.
• Diagnostic Assay Development: Employed in the development of clinical mass spectrometry assays for detecting metabolic disorders related to cholesterol synthesis.
• Stable Isotope Labeling: Acts as a labeled precursor for the synthesis of more complex isotopically labeled compounds in research and development.

Basic Information

Product Name	Mevalonic-1,2-13C2 Lactone
CAS No.	287111-36-8
Molecular Formula	C6H10O3 (with 13C at positions 1 & 2)
Molecular Weight	~132.1 g/mol (exact mass varies with isotopic enrichment)
Synonyms	(3R)-3,5-Dihydroxy-3-methylpentanoic acid 1,2-13C2 δ-lactone; (R)-Mevalonolactone-1,2-13C2; 3-Methyl-D-δ4-pentanolide-1,2-13C2; Mevalolactone-1,2-13C2; 6-Methyltetrahydro-2H-pyran-2,4(3H)-dione-1,2-13C2; 13C Labeled Mevalonic Acid Lactone; Isotopic Mevalonolactone
EINECS	Contact for details

Quality Control

Every batch of our Mevalonic-1,2-13C2 Lactone is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR (1H, 13C) for structural confirmation and isotopic enrichment verification, and HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % 13C at positions 1 & 2
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.