Description

D-[1,6-13C2]Fructose is a high-purity, stable isotope-labeled analog of fructose, specifically enriched with carbon-13 at the 1 and 6 positions. This compound is essential for advanced metabolic research and analytical applications, providing a critical tracer for precise quantification and pathway elucidation. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in isotope dilution mass spectrometry (IDMS), nuclear magnetic resonance (NMR) spectroscopy, and clinical diagnostics.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of fructose and related metabolites in complex biological matrices like blood, urine, and tissue samples.
• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify carbon flow through metabolic pathways such as glycolysis and the pentose phosphate pathway in cell cultures and in vivo studies.
• NMR Spectroscopy Studies: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of carbohydrate metabolism and enzyme mechanisms.
• Clinical Diagnostics & Assay Development: Employed in the calibration and validation of diagnostic kits and LC-MS/MS methods for metabolic disorder testing (e.g., diabetes, hereditary fructose intolerance).
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies to track the fate of sugar-based drug molecules or excipients.
• Nutritional Science Research: Enables detailed studies on fructose absorption, utilization, and its role in metabolic syndromes.

Basic Information

Product Name	D-[1,6-13C2]Fructose
CAS No.	287100-71-4
Molecular Formula	C6H12O6 (with 13C at positions 1 & 6)
Molecular Weight	182.15 g/mol (approx.)
Synonyms	1,6-13C2-Fructose; [1,6-13C2]-D-Fructose; D-Fructose-1,6-13C2; Fructose-1,6-13C2; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-1,6-13C2; Levulose-1,6-13C2; Fruit sugar-1,6-13C2; Stable Isotope Labeled Fructose
EINECS	Contact for details

Quality Control

Every batch of D-[1,6-13C2]Fructose is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and absence of biological contaminants. Our quality commitment aligns with the standards expected for research-grade biochemicals used in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99% at positions 1 & 6
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Bacterial Endotoxins	< 0.25 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.