Description

[1-13Cglc]Lactose Monohydrate CAS NO 287100-62-3 is a stable isotope-labeled form of lactose, where the glucose moiety is enriched with carbon-13 at the C-1 position. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing a non-radioactive tracer for accurate quantification. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic kits for use in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in in vitro and in vivo studies to elucidate glucose and galactose metabolism.
• Mass Spectrometry Internal Standard: Serves as a critical internal standard for the precise quantification of lactose and its metabolites in complex biological matrices via LC-MS/MS and GC-MS.
• NMR Spectroscopy: Employed in nuclear magnetic resonance studies for structural analysis and dynamic metabolic flux analysis.
• Pharmaceutical Development: Utilized in drug metabolism and pharmacokinetics (DMPK) studies for labeled drug formulations and bioavailability assessments.
• Clinical Diagnostics: Applied in the development and calibration of diagnostic assays for disorders of carbohydrate metabolism, such as lactose intolerance.
• Nutritional Research: Used to study lactose digestion, absorption, and the impact on gut microbiota in nutritional science.

Basic Information

Product Name	[1-13Cglc]Lactose Monohydrate
CAS No.	287100-62-3
Molecular Formula	C12H22O11 • H2O (with 13C labeling at specified position)
Molecular Weight	360.31 g/mol (for unlabeled form; contact for exact labeled MW)
Synonyms	4-O-β-D-Galactopyranosyl-α/β-D-[1-13C]glucopyranose Monohydrate; 13C-Labeled Lactose; Lactose-1-13C (glucose moiety); [1-13C]Glucose-Labeled Lactose; β-D-Galactopyranosyl-(1→4)-D-[1-13C]glucose Monohydrate; Stable Isotope-Labeled Lactose; Lactose (13C1, 99%)
EINECS	Contact for details

Quality Control

Every batch of [1-13Cglc]Lactose Monohydrate is manufactured and analyzed under strict quality systems. We ensure high chemical purity and isotopic enrichment, typically ≥98% chemical purity and ≥99% atom % 13C at the specified position, verified by NMR and HPLC-MS. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and specific tests are provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment (NMR)	≥99.0 atom % 13C
Specific Optical Rotation	+52.0° to +52.6°
Water Content (Karl Fischer)	4.5% - 5.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.