Description

D-Alanine-13C3 is a stable isotope-labeled analog of the non-proteinogenic D-enantiomer of the amino acid alanine, where three carbon atoms are replaced with the 13C isotope. This high-purity labeled compound is essential for advanced research requiring precise metabolic tracing and quantification in complex biological systems. It is a critical reagent for scientists in pharmaceutical development, metabolic research, and analytical chemistry who require definitive internal standards for mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a definitive quantitative standard in LC-MS and GC-MS analyses for studying alanine metabolism, bacterial cell wall biosynthesis, and D-amino acid function.
• Metabolic Pathway Tracing: Used in 13C-isotope labeling studies to elucidate metabolic fluxes, particularly in microbial systems, cancer metabolism, and neurological research.
• Pharmaceutical Research & Development: Critical for the pharmacokinetic (PK) and pharmacodynamic (PD) studies of new drug candidates, enabling accurate measurement of drug metabolites.
• NMR Spectroscopy: Provides a non-radioactive tracer for structural and dynamic studies of peptides, proteins, and enzymatic mechanisms.
• Microbiological Research: Investigates the role of D-alanine in bacterial peptidoglycan synthesis and antibiotic resistance mechanisms.
• Diagnostic Assay Development: Employed in the calibration and validation of clinical diagnostic kits targeting amino acid disorders or specific metabolic biomarkers.

Basic Information

Product Name	D-Alanine-13C3
CAS No.	286460-72-8
Molecular Formula	¹³C₃H₇NO₂
Molecular Weight	92.05 g/mol (for ¹³C₃)
Synonyms	(2R)-2-Aminopropanoic acid-13C3; (R)-Alanine-13C3; D-2-Aminopropionic acid-13C3; (R)-2-Aminopropanoic acid-13C3; D-Ala-13C3; D-α-Alanine-13C3; (R)-(-)-Alanine-13C3; Alanine-13C3 (D-form)
EINECS	Contact for details

Quality Control

Our D-Alanine-13C3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), chiral purity, and other critical parameters. We support compliance with cGMP and ISO 9001 standards for reliable and traceable material supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.