Description

(S)-1-(Diphenylphosphino)-2-Amino-3,3-Dimethylbutane CAS NO 286454-86-2 is a high-value chiral phosphine ligand, a critical component in asymmetric catalysis. Its unique structure enables the precise control of stereochemistry in complex organic transformations, directly impacting the efficiency and yield of advanced chemical synthesis. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high enantioselectivity and reliable performance in their catalytic processes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure pharmaceutical intermediates.
• Catalyst component in asymmetric carbon-carbon bond-forming reactions, such as cross-coupling and allylic substitution.
• Key reagent in the development and production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Use in agrochemical research for creating chiral herbicides, fungicides, and insecticides with improved efficacy.
• Facilitates asymmetric synthesis in academic and industrial research laboratories for novel compound libraries.
• Employed in the fine chemical industry for the manufacture of specialty chemicals, flavors, and fragrances.

Basic Information

Product Name	(S)-1-(Diphenylphosphino)-2-Amino-3,3-Dimethylbutane
CAS No.	286454-86-2
Molecular Formula	C18H24NP
Molecular Weight	285.37 g/mol
Synonyms	(S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane; (S)-2-Amino-3,3-dimethyl-1-(diphenylphosphino)butane; (S)-t-Bu-PHOX; (S)-tert-ButylPHOX; (S)-2-(Diphenylphosphino)-1-(1,1-dimethylethyl)ethylamine; (S)-2-(Diphenylphosphino)-1-(tert-butyl)ethylamine; (S)-PHOX Ligand; Chiral PHOX Ligand
EINECS	Contact for details

Quality Control

Our (S)-1-(Diphenylphosphino)-2-Amino-3,3-Dimethylbutane is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support development from laboratory to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.