Description

L-Asparagine-4-13C Monohydrate is a stable isotope-labeled analog of the amino acid L-asparagine, where the carbon atom at the 4-position is enriched with the 13C isotope. This compound is essential for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and manufacturers in the fields of pharmaceutical research, metabolic studies, and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Metabolic Pathway Tracing: Used as a 13C-labeled tracer in mass spectrometry (MS) and NMR studies to investigate amino acid metabolism and biosynthesis in biological systems.
• Pharmaceutical Research & Development: Serves as a critical reagent in the synthesis and development of isotopically labeled drug candidates and metabolites for pharmacokinetic and pharmacodynamic studies.
• Biochemical Assays: Employed in quantitative biochemical assays and diagnostic kit development where a stable isotope internal standard is required for accurate measurement.
• Nutritional Science Research: Applied in studies of protein metabolism, nitrogen balance, and the nutritional role of amino acids in humans and animals.
• NMR Spectroscopy Standard: Acts as a chemical shift reference or standard in complex mixture analysis due to its distinct 13C NMR signal.

Basic Information

Product Name	L-Asparagine-4-13C Monohydrate
CAS No.	286437-12-5
Molecular Formula	C413CH9N2O4 • H2O
Molecular Weight	151.12 g/mol (for 13C1 isotopologue)
Synonyms	(2S)-2-Amino-3-carbamoyl-4-(13C)propanoic acid monohydrate; L-Asparagine-4-13C hydrate; L-2-Aminosuccinamic-4-13C acid monohydrate; L-Asparagine-4-13C, monohydrate; Asn-4-13C; [4-13C]-L-Asparagine monohydrate
EINECS	Contact for details

Quality Control

Our L-Asparagine-4-13C Monohydrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and chiral integrity. Certificates of Analysis (COA) are provided, detailing specifications for assay, isotopic purity (atom % 13C), optical rotation, and related substances by HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (atom % 13C)	≥ 99%
Optical Rotation [α]20/D	+31.0° to +35.0° (c=2 in H2O)
Water Content (KF)	8.0% - 12.0%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.