Description

L-Glutamine-13C5 is a stable isotope-labeled analog of the essential amino acid L-glutamine, where all five carbon atoms are replaced with the 13C isotope. This high-purity compound is critical for advanced research requiring precise metabolic pathway tracing and quantification. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in mass spectrometry-based metabolomics, pharmacokinetic studies, and stable isotope-resolved metabolic profiling.

Application

• Metabolic Flux Analysis (MFA): As an internal standard for quantifying glutamine uptake and utilization in cell culture and in vivo studies.
• Mass Spectrometry (MS) & LC-MS/MS: Used as a labeled standard for the accurate and sensitive quantification of endogenous glutamine levels in complex biological matrices.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Enables the detailed study of glutamine metabolism and its role in cellular processes due to the 13C nuclei.
• Cancer Metabolism Research: Investigates the role of glutaminolysis in tumor cell proliferation and energy production.
• Drug Discovery & Development: Supports ADME (Absorption, Distribution, Metabolism, Excretion) studies for new therapeutic agents targeting amino acid pathways.
• Nutritional Science Research: Tracks the metabolic fate of glutamine in dietary and supplementation studies.

Basic Information

Product Name	L-Glutamine-13C5
CAS No.	285978-14-5
Molecular Formula	¹³C5H10N2O3
Molecular Weight	151.10 g/mol (for ¹³C5)
Synonyms	(2S)-2-Azaniumyl-4-carbamoyl(5-¹³C)butanoate; L-Glutamine (13C5); Glutamine-13C5; (S)-2,5-Diamino-5-oxopentanoic-13C5 acid; 13C5-L-Gln; [U-13C5]-L-Glutamine; 13C5 Labeled L-Glutamine; Stable Isotope Labeled L-Glutamine
EINECS	Contact for details

Quality Control

Our L-Glutamine-13C5 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥ 99 atom % 13C), chemical purity (by HPLC), and confirming identity and absence of critical impurities. We support compliance with relevant standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % ¹³C
Optical Rotation	[α]20/D: +6.0° to +8.0° (c=2 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.