Description

L-Serine-2-13C-15N is a stable isotope-labeled analog of the essential amino acid L-Serine, specifically enriched with carbon-13 at the 2-position and nitrogen-15. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing, protein structure elucidation, and quantitative proteomic analysis. It is primarily utilized by pharmaceutical companies, academic research institutions, and CROs (Contract Research Organizations) engaged in drug discovery, biomarker research, and nutritional studies.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, glycolysis, and serine biosynthesis pathways in cell cultures and model organisms.
• Quantitative Proteomics & Mass Spectrometry: Serves as an internal standard for the accurate quantification of proteins and peptides using techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• NMR Spectroscopy: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of proteins, enzymes, and their complexes.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of LC-MS/MS methods for tracking the absorption, distribution, metabolism, and excretion of novel drug candidates.
• Nutritional Research: Investigates protein synthesis rates, amino acid turnover, and metabolic disorders related to serine metabolism in clinical and preclinical studies.

Basic Information

Product Name	L-Serine-2-13C-15N
CAS No.	285977-90-4
Molecular Formula	C313CH715NO3
Molecular Weight	108.06 g/mol
Synonyms	(2S)-2-Azanyl-3-hydroxypropanoic-2-13C-15N acid; L-Serine-2-13C,15N; Serine-2-13C,15N; (S)-Serine-2-13C,15N; 13C,15N-L-Serine; Stable Isotope Labeled L-Serine; L-2-Amino-3-hydroxypropionic-2-13C-15N acid; Isotopic Tracer L-Serine
EINECS	Contact for details

Quality Control

Our L-Serine-2-13C-15N is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C and 15N), chemical purity, and chiral purity. We adhere to relevant standards for stable isotope-labeled compounds, ensuring reliability and consistency for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Chemical Purity (Titration)	≥ 98.0%
Optical Rotation	[α]D20: +13.5° to +15.5° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.