Description

L-Tyrosine-Ul-14C is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-Tyrosine, a critical building block for proteins and neurotransmitters. This radiolabeled compound is indispensable for advanced metabolic, pharmacokinetic, and biochemical tracer studies, enabling precise tracking of tyrosine pathways in biological systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in drug discovery and life science research.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-containing compounds or related drugs.
• Biochemical Pathway Analysis: Enables detailed mapping of tyrosine metabolic pathways, including its role in the synthesis of catecholamines (dopamine, norepinephrine, epinephrine), melanin, and thyroid hormones.
• Protein Turnover and Synthesis Research: Employed in studies measuring the rate of protein synthesis and degradation in various tissues and cell cultures.
• Receptor Binding and Autoradiography Assays: Serves as a precursor for synthesizing labeled ligands to study neurotransmitter receptors in the brain and nervous system.
• Environmental and Agricultural Tracer Studies: Applied in research on amino acid uptake and metabolism in plants and soil microorganisms.

Basic Information

Product Name	L-Tyrosine-Ul-14C
CAS No.	282733-43-1
Molecular Formula	C9H1114CNO3 * (typically as a salt, e.g., hydrochloride)
Molecular Weight	Contact for details (varies with specific salt form and isotopic enrichment)
Synonyms	(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid-U-14C; L-3-(4-Hydroxyphenyl)alanine-U-14C; 4-Hydroxy-L-phenylalanine-U-14C; Tyrosine (U-14C); [U-14C]-L-Tyrosine; Carbon-14 labeled L-Tyrosine; Uniformly labeled 14C-L-Tyrosine
EINECS	Contact for details

Quality Control

Every batch of L-Tyrosine-Ul-14C is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our quality commitment includes comprehensive analytical testing via HPLC with radiometric detection, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying batch-specific data on purity, specific activity (mCi/mmol or GBq/mmol), and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at or below -20°C. The solution (if supplied as such) should be stored according to the solvent's requirements. Always follow appropriate radiation safety protocols and local regulations for handling and storing radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or clear solution (solvent specified)
Identification (HPLC, NMR)	Conforms to reference standard
Radiochemical Purity (Radiometric HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	Customized (e.g., 50-600 mCi/mmol)
Radioisotopic Purity	≥ 99% Carbon-14
Solvent (if applicable)	Ethanol, Water, or specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.