Description

(S)-1-[(1R)-2-(Diphenylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a wide range of transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereofidelity, such as Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Asymmetric Allylic Substitution: Used in Tsuji-Trost and related reactions to construct chiral centers with excellent enantiomeric excess.
• Pharmaceutical Intermediate Synthesis: Key for the production of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced chiral building blocks.
• Agrochemical Product Development: Enables the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often stereospecific.
• Academic & Industrial R&D: A vital tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Product Name	(S)-1-[(1R)-2-(Diphenylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine
CAS No.	268220-91-3
Molecular Formula	C32H38FeP2
Molecular Weight	540.44 g/mol
Synonyms	(S,R)-Josiphos; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi(tert-butyl)phosphine; Josiphos SL-J009-1; (S)-1-((R)-2-(Diphenylphosphino)ferrocenyl)ethyldi-tert-butylphosphine; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; (1S)-1-[(1R)-2-(Diphenylphosphanyl)ferrocen-1-yl]ethyldi(tert-butyl)phosphane
EINECS	Contact for details

Quality Control

Our (S)-1-[(1R)-2-(Diphenylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and elemental analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications to ensure compliance with your research and process development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.