Description

trans-Abacavir Hydrochloride is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for research and development in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs), a key class of antiviral agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of antiviral therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of Abacavir and related antiviral prodrugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) testing in pharmaceutical manufacturing.
• Research & Development: Serves as a crucial material for pharmacological studies, metabolic pathway research, and structure-activity relationship (SAR) investigations of NRTIs.
• Impurity Profiling: Employed as a certified impurity standard to monitor and control stereoisomeric purity in active pharmaceutical ingredient (API) batches.
• Regulatory Submissions: Provides essential data for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).

Basic Information

Product Name	trans-Abacavir Hydrochloride
CAS No.	267668-71-3
Molecular Formula	C14H19ClN6O
Molecular Weight	322.80 g/mol
Synonyms	trans-Abacavir HCl; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; Abacavir Related Compound H (trans-isomer); (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; trans-ABC HCl; Cyclopropavir Impurity; Abacavir trans-Isomer Hydrochloride
EINECS	Contact for details

Quality Control

Our trans-Abacavir Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory requirements for API synthesis and impurity control.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (trans-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.