Description

Edonentan CAS NO 264609-13-4 is a selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential to modulate the endothelin system. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for investigating cardiovascular and renal pathologies, as well as for the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the discovery and synthesis of novel endothelin receptor antagonists.
• Cardiovascular Disease Studies: Used in preclinical research to investigate conditions such as pulmonary arterial hypertension, heart failure, and systemic hypertension.
• Renal Function Research: Applied in studies exploring the role of endothelin in chronic kidney disease, diabetic nephropathy, and other renal disorders.
• Biochemical Assay Development: Serves as a critical tool for developing and validating high-throughput screening assays targeting the ETA receptor.
• Metabolic Pathway Analysis: Employed in pharmacological studies to understand drug metabolism, pharmacokinetics, and structure-activity relationships (SAR).
• Academic & Institutional Research: Used in university and institutional labs for fundamental research into G-protein coupled receptor (GPCR) signaling and function.

Basic Information

Product Name	Edonentan
CAS No.	264609-13-4
Molecular Formula	C29H41N5O6S
Molecular Weight	587.73 g/mol
Synonyms	Edonentan; BSF 208075; J-104132; LU 208075; SB 217242; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-[(2,6-diethylphenyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; 1-[2-[(2,6-Diethylphenyl)amino]-2-oxoethyl]-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Edonentan is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.