Description

(S)-Methyl 2-Amino-3-Benzamidopropanoate Hydrochloride is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of pharmaceuticals and bioactive peptides, offering precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptide-based drug development.
• Peptide Chemistry: Used as a protected amino acid ester in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific residues.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and enzyme substrate research.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to generate enantiomerically pure compounds.
• Protecting Group Strategy: The methyl ester and benzamide groups provide orthogonal protection for amine and carboxylic acid functionalities during multi-step syntheses.

Basic Information

Product Name	(S)-Methyl 2-Amino-3-Benzamidopropanoate Hydrochloride
CAS No.	264275-33-4
Molecular Formula	C11H15ClN2O3
Molecular Weight	258.70 g/mol
Synonyms	L-2-Amino-3-benzamidopropionic acid methyl ester hydrochloride; Methyl (2S)-2-amino-3-(benzoylamino)propanoate hydrochloride; Methyl L-2-amino-3-benzamidopropionate HCl; (S)-Methyl 2-amino-3-(benzoylamino)propanoate hydrochloride; Nα-Benzoyl-L-2,3-diaminopropionic acid methyl ester hydrochloride; Methyl N-benzoyl-L-2,3-diaminopropanoate hydrochloride; Benzoyl-DL-2,3-diaminopropionic acid methyl ester hydrochloride (related); CAS 264275-33-4
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-Amino-3-Benzamidopropanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.