Description

D-[1,2-13C2]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C1 and C2 positions. This compound is an essential tracer molecule for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and metabolic flux in biological systems. It is critically needed by researchers and analytical laboratories in the pharmaceutical, biotechnology, and academic sectors for applications in drug development, metabolic disorder studies, and NMR spectroscopy.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates and network regulation in cell cultures and tissues.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in isotope dilution mass spectrometry for the accurate quantification of glucose and its metabolites in preclinical and clinical studies.
• NMR Spectroscopy: Serves as a standard and substrate for 13C-NMR studies to elucidate metabolic pathways and enzyme mechanisms.
• Diabetes & Metabolic Disease Research: Facilitates detailed investigation into glucose metabolism, insulin resistance, and related disorders.
• Stable Isotope Labeling: Acts as a precursor for the synthesis of other 13C-labeled compounds in biochemical research.
• Biomarker Discovery & Validation: Used in mass spectrometry-based assays to discover and validate metabolic biomarkers.

Basic Information

Product Name	D-[1,2-13C2]Glucose
CAS No.	261728-61-4
Molecular Formula	C6H12O6 (13C at C1 & C2)
Molecular Weight	182.15 g/mol (for 13C2 isotopologue)
Synonyms	D-Glucose-1,2-13C2; (1,2-13C2)-D-Glucose; D-(+)-Glucose-1,2-13C2; 1,2-13C2-D-Glucose; [1,2-13C]Glucose; D-Glucose (1,2-13C2); Isotopic D-Glucose; 13C-Labeled D-Glucose
EINECS	Contact for details

Quality Control

Our D-[1,2-13C2]Glucose is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR and LC/MS to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Enrichment (Positional)	≥ 99% at C1 & C2
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.