Description

Sabiporide is a selective and potent inhibitor of the Na+/H+ exchanger isoform 1 (NHE-1), a key regulator of intracellular pH and sodium homeostasis. This compound is of significant interest for its potential cardioprotective effects, particularly in the context of ischemia-reperfusion injury. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in cardiovascular disease research, drug discovery, and preclinical studies.

Application

• Cardiovascular Research: Investigation of myocardial ischemia-reperfusion injury mechanisms and potential therapeutic interventions.
• Drug Discovery & Development: Serving as a reference standard, pharmacologic tool, or lead compound in NHE-1 inhibitor programs.
• Preclinical Studies: Evaluation of cardioprotective efficacy and safety profiles in animal models of heart disease.
• Biochemical Assays: Used in in vitro studies to elucidate the role of NHE-1 in cellular signaling pathways related to apoptosis and necrosis.
• Academic Research: Fundamental research into ion transport physiology and pathophysiology.

Basic Information

Product Name	Sabiporide
CAS No.	261505-80-0
Molecular Formula	C16H21N3O3S
Molecular Weight	335.42 g/mol
Synonyms	Sabiporide; 4-Isopropyl-3-methylsulfonylbenzoylguanidine methanesulfonate; SM-20550; (4-Isopropyl-3-methylsulfonylbenzoyl)guanidine methanesulfonate; NHE-1 Inhibitor; Sodium-Hydrogen Exchanger Inhibitor; BMS-284640
EINECS	Contact for details

Quality Control

Our Sabiporide is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various research-grade specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.