Description

Methyl 2'-Fluoro[1,1'-Biphenyl]-4-Carboxylate is a high-purity fluorinated biphenyl derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its value lies in the precise introduction of fluorine and ester functionalities, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas like oncology, CNS disorders, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides with enhanced efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes.
• Organic Synthesis Building Block: Employed in Suzuki-Miyaura and other cross-coupling reactions to construct complex biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring structure-activity relationships (SAR) in medicinal chemistry programs.

Basic Information

Product Name	Methyl 2'-Fluoro[1,1'-Biphenyl]-4-Carboxylate
CAS No.	259269-56-2
Molecular Formula	C14H11FO2
Molecular Weight	230.24 g/mol
Synonyms	2'-Fluoro-4-biphenylcarboxylic acid methyl ester; Methyl 2'-fluorobiphenyl-4-carboxylate; 4-(Methoxycarbonyl)-2'-fluorobiphenyl; [1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-, methyl ester; 2'-Fluoro[1,1'-biphenyl]-4-carboxylic acid methyl ester; 2-Fluorobiphenyl-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2'-Fluoro[1,1'-Biphenyl]-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.