Description

2-Azetidinecarboxylic Acid, 1-(Trifluoroacetyl)-, (2R)- (9Ci) is a high-value, chiral azetidine derivative, a crucial building block in advanced organic synthesis. Its significance lies in its role as a protected form of (R)-azetidine-2-carboxylic acid, enabling precise stereochemical control in the development of novel pharmaceuticals and bioactive compounds. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme inhibitors, and other therapeutic agents.
• Peptidomimetics Research: Used to incorporate the constrained azetidine ring into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Development: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific chiral activity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective catalytic reactions.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring specific molecular architectures.

Basic Information

Product Name	2-Azetidinecarboxylic Acid, 1-(Trifluoroacetyl)-, (2R)- (9Ci)
CAS No.	255883-13-7
Molecular Formula	C6H6F3NO3
Molecular Weight	197.11 g/mol
Synonyms	(R)-1-(Trifluoroacetyl)azetidine-2-carboxylic Acid; (2R)-1-(Trifluoroacetyl)azetidine-2-carboxylic Acid; (R)-N-Trifluoroacetyl-2-azetidinecarboxylic Acid; (R)-Azetidine-2-carboxylic Acid, N-Trifluoroacetyl Derivative; 1-Trifluoroacetyl-D-azetidine-2-carboxylic Acid; (R)-N-TFA-Azetidine-2-carboxylic Acid; (R)-1-TFA-Azetidine-2-carboxylic Acid; (R)-N-Trifluoroacetylazetidine-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxylic Acid, 1-(Trifluoroacetyl)-, (2R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.