Description

2-Chloro-4-Trifluoromethylphenylboronic Acid is a high-purity organoboron building block essential for modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and chlorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the chlorotrifluoromethylphenyl group imparts specific biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-4-Trifluoromethylphenylboronic Acid
CAS No.	254993-59-4
Molecular Formula	C7H5BClF3O2
Molecular Weight	223.38 g/mol
Synonyms	(2-Chloro-4-(trifluoromethyl)phenyl)boronic Acid; 2-Chloro-α,α,α-trifluoro-p-tolylboronic Acid; 2-Chloro-4-trifluoromethylbenzeneboronic Acid; Boronic acid, B-[2-chloro-4-(trifluoromethyl)phenyl]-; 2-Chloro-4-(trifluoromethyl)benzeneboronic Acid; 2-Chloro-4-trifluoromethylphenylboronic acid; 2-Chloro-4-trifluoromethylphenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.