Description

(2R,4S)-1-tert-Butyl 2-Methyl 4-Aminopyrrolidine-1,2-Dicarboxylate is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, particularly for creating active pharmaceutical ingredients (APIs) with specific stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Protease Inhibitor Development: Serves as a core structural element in the research and production of protease inhibitor candidates.
• Chemical Biology & Medicinal Chemistry: Employed in the design and construction of molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetics: Acts as a constrained scaffold for developing peptidomimetic compounds with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Potential intermediate for creating chiral active ingredients in advanced crop protection agents.

Basic Information

Product Name	(2R,4S)-1-tert-Butyl 2-Methyl 4-Aminopyrrolidine-1,2-Dicarboxylate
CAS No.	254881-77-1
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	1-Boc-2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate; (2R,4S)-4-Amino-1-(tert-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine; (2R,4S)-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-aminopyrrolidine; (2R,4S)-4-Amino-1-Boc-pyrrolidine-2-carboxylic acid methyl ester; 1-N-Boc-2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate; (2R,4S)-1-Boc-4-aminopyrrolidine-2-carboxylic acid methyl ester; Methyl (2R,4S)-4-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our (2R,4S)-1-tert-Butyl 2-Methyl 4-Aminopyrrolidine-1,2-Dicarboxylate is manufactured under cGMP-compliant conditions to ensure the highest standards of purity and consistency for pharmaceutical applications. All batches undergo rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard identification methods. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.