Description

Ataciguat CAS NO 254877-67-3 is a high-purity, small molecule pharmaceutical intermediate and research chemical. It is a soluble guanylate cyclase (sGC) stimulator of significant interest in cardiovascular and pulmonary research. This compound is essential for researchers and manufacturers in the pharmaceutical development sector, particularly those focused on novel therapies for hypertension, heart failure, and pulmonary arterial hypertension.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced investigational drugs targeting soluble guanylate cyclase (sGC).
• Cardiovascular Research: Used in preclinical studies to investigate mechanisms for treating systemic hypertension and chronic heart failure.
• Pulmonary Research: Critical for developing and testing potential treatments for pulmonary arterial hypertension (PAH).
• Biochemical Assay Development: Serves as a reference standard and active compound in high-throughput screening and in vitro pharmacological assays.
• Mechanistic Studies: Employed to study the NO-sGC-cGMP signaling pathway and its role in vascular smooth muscle relaxation.
• GMP Manufacturing: Supplied as a starting material or intermediate for cGMP production of clinical trial materials.

Basic Information

Product Name	Ataciguat
CAS No.	254877-67-3
Molecular Formula	C20H21N5O4S
Molecular Weight	427.48 g/mol
Synonyms	Ataciguat; BAY 60-4552; 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4-pyrimidinamine; 2-{1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}-5-(morpholin-4-yl)pyrimidin-4-amine; BAY-60-4552; BAY 60 4552; sGC Stimulator BAY 60-4552
EINECS	Contact for details

Quality Control

Our Ataciguat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry, well-ventilated area. Keep the container sealed to protect this moisture-sensitive compound from humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.