Description

Alisporivir is a potent, non-immunosuppressive cyclophilin inhibitor with significant antiviral and anti-fibrotic properties. Its primary value lies in its unique mechanism of action, targeting host cell proteins to inhibit viral replication, which makes it a compound of high interest for therapeutic development. This product is essential for pharmaceutical R&D teams, medicinal chemists, and contract research organizations (CROs) focused on virology, hepatology, and fibrosis research.

Application

• Antiviral Research: Key investigational agent for studying host-targeting antiviral therapies against Hepatitis C Virus (HCV), coronaviruses, and other RNA viruses.
• Drug Discovery & Development: Serves as a critical reference standard, pharmacologically active compound, and lead molecule in preclinical studies.
• Mechanistic Studies: Used to investigate the role of cyclophilins in cellular processes, including protein folding, immune response modulation, and mitochondrial function.
• Anti-fibrotic Research: Explored for its potential to attenuate fibrosis in liver, lung, and cardiac tissues by modulating cyclophilin-D activity.
• Biochemical Assays: Utilized as a selective inhibitor in enzymatic assays to study cyclophilin A, B, and D isoforms.
• Academic Research: A valuable tool compound in university and institutional labs for virology, cell biology, and pathophysiology research.

Basic Information

Product Name	Alisporivir
CAS No.	254435-95-5
Molecular Formula	C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight	1200.62 g/mol
Synonyms	Debio 025; UNIL-025; [D-MeAla]³-[EtVal]⁴-CsA; Alisporivir dihydrochloride; Cyclosporin Derivative Debio 025; Non-immunosuppressive Cyclosporin A Analogue; 3-(2-Methylalanyl)-4-(N-ethyl-L-valyl)cyclosporin
EINECS	Contact for details

Quality Control

Every batch of Alisporivir is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your research, including identity confirmation by spectroscopic methods and purity determination by HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results for purity, related substances, and residual solvents. Our quality commitment ensures material integrity for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.