Description

28-Epirapamycin is a structural analog of the potent immunosuppressant and mTOR inhibitor, rapamycin (sirolimus). This compound is of significant interest in pharmaceutical research and development due to its potential for modified biological activity and pharmacokinetic properties compared to the parent molecule. It serves as a critical reference standard and a key intermediate for researchers in the fields of immunology, oncology, and aging. Professionals in pharmaceutical R&D, contract research organizations (CROs), and academic institutions require this high-purity compound for mechanism-of-action studies, assay development, and the synthesis of novel therapeutic candidates.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of rapamycin analogs in research and quality control laboratories.
• Biochemical Research: Employed in studies investigating the mTOR (mechanistic target of rapamycin) signaling pathway and its role in cell growth, proliferation, and autophagy.
• Drug Discovery & Development: Serves as a crucial intermediate or lead compound for synthesizing and evaluating new rapamycin derivatives with potentially improved efficacy or safety profiles.
• Immunology Studies: Utilized in preclinical research to explore immunosuppressive mechanisms and develop new therapies for autoimmune diseases and organ transplantation.
• Oncology Research: Applied in cancer research to study the effects of mTOR inhibition on tumor cell proliferation and survival.
• Academic Research: A vital tool for universities and research institutes conducting fundamental biological and chemical research.

Basic Information

Product Name	28-Epirapamycin
CAS No.	253431-35-5
Molecular Formula	C51H79NO13
Molecular Weight	914.18 g/mol
Synonyms	28-Episirolimus; 28-Epi-rapamycin; 28-Epi-sirolimus; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
EINECS	Contact for details

Quality Control

Our 28-Epirapamycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.