Description

2,4,5-Trifluorocinnamic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. Its unique trifluoromethyl-substituted cinnamate structure makes it a critical intermediate for creating compounds with enhanced metabolic stability and bioavailability. This product is primarily demanded by pharmaceutical R&D and agrochemical manufacturers for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for next-generation herbicides and fungicides, where the fluorine atoms improve lipophilicity and target binding.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials and emissive layer components.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Peptide Mimetics & PROTACs: Incorporated into peptide backbones and Proteolysis-Targeting Chimeras (PROTACs) to enhance cell permeability and stability.

Basic Information

Product Name	2,4,5-Trifluorocinnamic Acid
CAS No.	247170-17-8
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,4,5-Trifluorophenyl)acrylic Acid; (E)-3-(2,4,5-Trifluorophenyl)-2-propenoic Acid; trans-2,4,5-Trifluorocinnamic Acid; 2,4,5-Trifluorocinnameic Acid; β-(2,4,5-Trifluorophenyl)acrylic Acid; 247170-17-8; 2,4,5-Trifluoro-trans-cinnamic Acid
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.