Description

(R)-1-[(S)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]-Ethyldi-tert-Butylphosphine is a highly specialized, chiral ferrocenylphosphine ligand crucial for enabling asymmetric synthesis in advanced pharmaceutical and fine chemical manufacturing. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in transition-metal-catalyzed reactions, such as hydrogenations and cross-couplings. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control to develop novel active ingredients and high-value intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure pharmaceutical intermediates.
• Catalyst component in asymmetric C-C bond-forming reactions, including cross-coupling and allylic substitution.
• Critical reagent for process research and development (PR&D) in the scale-up of chiral active pharmaceutical ingredients (APIs).
• Use in academic and industrial research for developing new catalytic methodologies in organic synthesis.
• Enabling technology for the production of agrochemicals and flavors & fragrances requiring specific stereochemistry.
• Precursor for the preparation of tailored catalyst systems used in fine chemical manufacturing.

Basic Information

Product Name	(R)-1-[(S)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]-Ethyldi-tert-Butylphosphine
CAS No.	246231-79-8
Molecular Formula	C41H40F6FeP2
Molecular Weight	756.54 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis[4-(trifluoromethyl)phenyl]phosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos ligand SL-J009-1; (R)-1-[(S)-2-[Bis(4-trifluoromethylphenyl)phosphino]ferrocenyl]ethyldi(tert-butyl)phosphine; (R)-1-[(S)-2-(Di(4-(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; (R)-1-[(S)-2-[Bis(4-(trifluoromethyl)phenyl)phosphino]ferrocenyl]ethylbis(1,1-dimethylethyl)phosphine; SL-J009-1; Chiral Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.