Description

Genistein 4’-β-D-Glucuronide is a major, physiologically relevant metabolite of the soy isoflavone genistein. This compound is critical for research into the bioavailability, pharmacokinetics, and biological activity of dietary phytoestrogens. It serves as a vital analytical reference standard and a key intermediate for biochemical studies. Researchers in pharmaceutical development, nutraceutical science, and clinical diagnostics rely on this high-purity metabolite for accurate quantification and metabolic pathway investigation.

Application

• Analytical Reference Standard: Primary use for the quantification of genistein metabolites in biological matrices (plasma, urine, tissues) via HPLC, LC-MS, and LC-MS/MS methods.
• Pharmacokinetic & Metabolism Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profiles of genistein in preclinical and clinical research.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving glucuronidation (UGT enzymes) and deconjugation processes.
• Nutraceutical & Functional Food Research: Supports studies on the bioactivity, efficacy, and safety assessment of soy-based supplements and ingredients.
• Pharmaceutical Development: Acts as a critical biomarker and reference compound in drug development programs targeting estrogen-related pathways.
• Quality Control & Method Validation: Serves as a certified standard for validating analytical methods in quality control laboratories for dietary supplements and pharmaceutical products.

Basic Information

Product Name	Genistein 4’-β-D-Glucuronide
CAS No.	245084-07-5
Molecular Formula	C21H18O11
Molecular Weight	446.36 g/mol
Synonyms	Genistein 4'-Glucuronide; Genistein 4'-O-β-D-Glucuronide; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 4'-β-D-Glucopyranosiduronic Acid; 4'-O-β-D-Glucuronosylgenistein; Genistein 4'-O-Glucuronide; Genistein 4'-β-D-Glucuronide; Genistein 4'-Glucuronide (major metabolite)
EINECS	Contact for details

Quality Control

Our Genistein 4’-β-D-Glucuronide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.