Description

Dapivirine,4-[[4-(2,4,6-Trimethylphenyl)Amino]Pyrimidin-2-Yl]Amino]Benzonitrile is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) compound of significant pharmaceutical interest. Its primary value lies in its potent and specific antiviral activity, making it a critical intermediate for advanced therapeutic research and development. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers focused on developing next-generation antiviral agents and microbicides.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of Dapivirine and related NNRTI drug candidates.
• Antiviral Research: Used as a reference standard and active material in preclinical studies targeting HIV-1 and other retroviruses.
• Microbicide Development: Investigated for incorporation into topical formulations, such as gels and intravaginal rings, for HIV prevention.
• Biochemical Assays: Employed in enzymatic inhibition studies to evaluate reverse transcriptase activity and mechanism of action.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Supports virology and medicinal chemistry programs in universities and research institutes.

Basic Information

Product Name	Dapivirine,4-[[4-(2,4,6-Trimethylphenyl)Amino]Pyrimidin-2-Yl]Amino]Benzonitrile
CAS No.	244767-67-7
Molecular Formula	C20H19N5
Molecular Weight	329.40 g/mol
Synonyms	4-[[4-[(2,4,6-Trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile; TMC120; Dapivirine Intermediate; 4-[[4-(2,4,6-Trimethylanilino)pyrimidin-2-yl]amino]benzonitrile; 244767-67-7; UNII-1K5K5W5DRI; TMC 120
EINECS	Contact for details

Quality Control

Our Dapivirine intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.