Description

2,3,6-Trifluorocinnamic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role in introducing the trifluoromethylphenyl moiety, which can significantly alter the physicochemical properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and kinase-targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atoms contribute to improved lipophilicity and membrane permeability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Employed in the creation of electron-transport materials and host compounds for efficient electroluminescent devices.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile building block for exploring new chemical space in medicinal and materials chemistry programs.

Basic Information

Product Name	2,3,6-Trifluorocinnamic Acid
CAS No.	230295-12-2
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,3,6-Trifluorophenyl)prop-2-enoic acid; 2,3,6-Trifluorocinnamic acid; trans-2,3,6-Trifluorocinnamic Acid; (E)-3-(2,3,6-Trifluorophenyl)acrylic acid; β-(2,3,6-Trifluorophenyl)acrylic acid; 230295-12-2; 2,3,6-Trifluoro-trans-cinnamic acid
EINECS	Contact for details

Quality Control

Every batch of 2,3,6-Trifluorocinnamic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.