Description

3,5-Bis(Trifluoromethyl)Mandelic Acid is a high-value fluorinated mandelic acid derivative, distinguished by its two trifluoromethyl groups which impart unique electronic and steric properties. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering significant advantages in modulating the lipophilicity and metabolic stability of target molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or modifier in the development of fluorinated polymers with specialized surface properties and chemical resistance.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biological molecules for metabolic pathway studies and imaging applications.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Mandelic Acid
CAS No.	228107-82-2
Molecular Formula	C10H6F6O3
Molecular Weight	288.14 g/mol
Synonyms	2-Hydroxy-2-[3,5-bis(trifluoromethyl)phenyl]acetic Acid; α-Hydroxy-3,5-bis(trifluoromethyl)benzeneacetic Acid; 3,5-Bis(trifluoromethyl)mandelic Acid; (RS)-2-Hydroxy-2-(3,5-bis(trifluoromethyl)phenyl)acetic Acid; DL-3,5-Bis(trifluoromethyl)mandelic Acid; (±)-3,5-Bis(trifluoromethyl)mandelic Acid; 3,5-Bis(trifluoromethyl)phenylglycolic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Mandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	Racemic mixture (DL-Form)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.