Description

Fosamprenavir Calcium CAS NO 226700-81-8 is the calcium salt of the prodrug fosamprenavir, designed to enhance the oral bioavailability of the active protease inhibitor, amprenavir. This compound is a critical active pharmaceutical ingredient (API) in the global fight against Human Immunodeficiency Virus (HIV) infection. It is primarily required by pharmaceutical manufacturers engaged in the development and production of antiretroviral combination therapies, serving as a cornerstone in treatment regimens for HIV-1.

Application

• Antiretroviral Drug Manufacturing: Primary use as the active pharmaceutical ingredient (API) in the synthesis of fosamprenavir calcium tablets.
• HIV-1 Combination Therapy: A key component in fixed-dose combination (FDC) drugs used for the treatment of HIV-1 infection in adults and pediatric patients.
• Pharmaceutical R&D: Serves as a reference standard and starting material in research for next-generation protease inhibitors and improved drug formulations.
• Generic Drug Production: Essential for manufacturers producing bioequivalent versions of branded antiretroviral medications.
• Clinical Trial Material (CTM): Used in the production of batches for clinical studies investigating new treatment protocols or patient populations.

Basic Information

Product Name	Fosamprenavir Calcium
CAS No.	226700-81-8
Molecular Formula	C₂₅H₃₄CaN₃O₉PS
Molecular Weight	623.66 g/mol
Synonyms	Fosamprenavir Calcium Salt; GW 433908G; (3S)-Tetrahydro-3-furyl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate Sulfate (Ester) Calcium Salt (2:1); Amprenavir Phosphate Ester Calcium Salt; Lexiva API (Calcium Salt); Telzir API (Calcium Salt); Prozei API (Calcium Salt)
EINECS	Contact for details

Quality Control

Our Fosamprenavir Calcium is manufactured under strict quality management systems, targeting compliance with current Good Manufacturing Practices (cGMP) for active pharmaceutical ingredients. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) is provided with every shipment, detailing specifications and results for critical parameters such as purity, related substances, and heavy metals to ensure it meets the stringent requirements of global pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.