Description

Fosamprenavir Sodium is the water-soluble prodrug of the potent HIV-1 protease inhibitor, amprenavir. This compound is critical for enhancing the bioavailability and patient compliance of antiretroviral therapy. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced antiretroviral medications for the treatment of HIV-1 infection.

Application

• Active Pharmaceutical Ingredient (API): Core component in the formulation of antiretroviral drugs for HIV-1 treatment.
• Fixed-Dose Combination Therapies: Used in combination with other antiretroviral agents to create simplified, multi-drug regimens.
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the discovery of new protease inhibitors and therapeutic protocols.
• Generic Drug Manufacturing: Essential for producing bioequivalent versions of branded antiretroviral medications containing fosamprenavir.
• Clinical Trial Material: Supplied as a high-purity compound for use in preclinical and clinical studies.

Basic Information

Product Name	Fosamprenavir Sodium
CAS No.	226700-80-7
Molecular Formula	C25H34N3NaO9PS
Molecular Weight	621.57 g/mol
Synonyms	Fosamprenavir Calcium (Salt Form); GW 433908; GW433908A; (3S)-Tetrahydro-3-furyl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamate Monosodium Salt; Lexiva (Brand Name); Telzir (Brand Name); Amprenavir Phosphate Prodrug; Fosamprenavirum Natricum
EINECS	Contact for details

Quality Control

Our Fosamprenavir Sodium is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest standards for pharmaceutical use. Quality is assured through compliance with current Good Manufacturing Practices (cGMP) and relevant ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.