Description

Fosamprenavir is a prodrug of the potent HIV-1 protease inhibitor amprenavir, designed to significantly improve oral bioavailability and patient compliance. This compound is a critical active pharmaceutical ingredient (API) in the global fight against Human Immunodeficiency Virus (HIV) infection. It is essential for pharmaceutical manufacturers developing and producing antiretroviral combination therapies, primarily for the treatment of HIV-1 in adults and pediatric patients.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of antiretroviral medications.
• Key component in fixed-dose combination therapies for the treatment of HIV-1 infection.
• Used in the manufacture of oral tablets, including both immediate-release and pediatric formulations.
• Critical for research and development of next-generation protease inhibitor-based treatments.
• Reference standard in analytical laboratories for quality control and method development.
• Starting material or intermediate in advanced pharmaceutical synthesis.

Basic Information

Product Name	Fosamprenavir
CAS No.	226700-79-4
Molecular Formula	C25H36N3O9PS
Molecular Weight	585.61 g/mol
Synonyms	Fosamprenavir Calcium; GW 433908; VX-175; (3S)-Tetrahydro-3-furyl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamate; Lexiva® (Brand Name); Telzir® (Brand Name); Fosamprenavirum; Amprenavir Phosphate Prodrug
EINECS	Contact for details

Quality Control

Our Fosamprenavir is manufactured under strict quality systems to meet the exacting standards of the global pharmaceutical industry. Every batch is supported by a comprehensive Certificate of Analysis (COA) confirming identity, purity, and potency. We adhere to ICH Q7 guidelines and can supply material suitable for use under cGMP (current Good Manufacturing Practice) conditions for API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.