Description

4-Aminomethyl-3-Fluoro-Benzoic Acid Methyl Ester is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its bifunctional nature, featuring both a reactive amino group and a protected carboxylic acid moiety, which facilitates its incorporation into complex molecular architectures. It is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, particularly as a key intermediate in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and amino group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics and Bio-conjugation: The aminomethyl group allows for coupling reactions, making it useful for constructing peptide analogs and linker molecules in bioconjugation chemistry.
• Material Science Research: Employed in the synthesis of specialty polymers, dyes, and liquid crystals where fluorinated aromatic units are required to modify physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated benzylamine derivatives.

Basic Information

Product Name	4-Aminomethyl-3-Fluoro-Benzoic Acid Methyl Ester
CAS No.	225528-27-8
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	Methyl 3-Fluoro-4-(aminomethyl)benzoate; 3-Fluoro-4-(aminomethyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(aminomethyl)-3-fluoro-, methyl ester; Methyl 4-(aminomethyl)-3-fluorobenzoate; 4-(Aminomethyl)-3-fluorobenzoic acid methyl ester; 3-Fluoro-4-aminomethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 4-Aminomethyl-3-Fluoro-Benzoic Acid Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.