Description

Bis(7)-Tacrine is a potent, dimeric derivative of tacrine, designed as a high-affinity acetylcholinesterase (AChE) inhibitor. This compound is of significant interest for its enhanced potency and selectivity compared to its monomeric counterpart, making it a valuable research tool in neuropharmacology. It is primarily utilized by pharmaceutical researchers and academic institutions investigating Alzheimer's disease, cognitive enhancement, and cholinergic system modulation.

Application

• Neuroscience Research: A key pharmacological tool for studying acetylcholinesterase inhibition kinetics and mechanisms.
• Drug Discovery: Serves as a lead compound or reference standard in the development of novel therapeutics for Alzheimer's disease and other cognitive disorders.
• Biochemical Assays: Used in in vitro enzymatic assays to evaluate AChE activity and screen for potential inhibitors.
• Academic & Preclinical Studies: Facilitates research into cholinergic neurotransmission, memory formation, and neuroprotection in animal models.
• Reference Standard: Employed for analytical method development, validation, and quality control in related pharmaceutical research.

Basic Information

Product Name	Bis(7)-Tacrine
CAS No.	224445-12-9
Molecular Formula	C30H28N4
Molecular Weight	444.57 g/mol
Synonyms	Bis(7)-Tacrine; Bis(7)tacrine; 1,7-Heptanediyl-bis-9-amino-1,2,3,4-tetrahydroacridine; 9-Amino-1,2,3,4-tetrahydroacridine, 1,7-heptanediylbis-; Heptamethylene-linked bis-tacrine; Dimeric tacrine; AChE dimeric inhibitor
EINECS	Contact for details

Quality Control

Our Bis(7)-Tacrine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.