Description

L-Cysteine-1-13C is a stable isotope-labeled derivative of the essential amino acid L-Cysteine, where the carbon atom at the 1-position is enriched with the 13C isotope. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing, protein structure elucidation, and quantitative analysis in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications requiring high isotopic purity and chemical stability.

Application

• Isotope-Labeled Internal Standards: For accurate quantification of cysteine and related metabolites in complex biological matrices using mass spectrometry (LC-MS, GC-MS).
• Metabolic Flux Analysis (MFA): As a tracer to study sulfur amino acid metabolism, glutathione synthesis, and cellular redox states in vivo and in vitro.
• NMR Spectroscopy Studies: For protein and peptide structural analysis, where the 13C label provides a non-perturbing probe for nuclear magnetic resonance experiments.
• Pharmaceutical Research: In the development and pharmacokinetic/pharmacodynamic (PK/PD) studies of drugs targeting cysteine-dependent pathways.
• Nutritional Science Research: To investigate the bioavailability, turnover, and functional role of cysteine in dietary and clinical studies.
• Biochemical Pathway Elucidation: To trace the incorporation of cysteine into proteins, peptides (like glutathione), and other biomolecules.

Basic Information

Product Name	L-Cysteine-1-13C
CAS No.	224054-24-4
Molecular Formula	C313CH7NO2S
Molecular Weight	122.16 g/mol (for 13C1 isotopologue)
Synonyms	(2R)-2-Amino-3-sulfanyl-1-13C-propanoic acid; L-Cysteine-1-13C; L-Cysteine (1-13C); 1-13C-L-Cysteine; [1-13C]-L-Cysteine; Cysteine-1-13C; (R)-2-Amino-3-mercapto-1-13C-propionic acid
EINECS	Contact for details

Quality Control

Our L-Cysteine-1-13C is produced under strict quality management systems to ensure the highest standards of isotopic and chemical purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically >99 atom % 13C), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a dry environment. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: +8.5° to +10.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.