Description

[1,1'-Biphenyl]-4-Methanamine, .Alpha.-Methyl-, (.Alpha.R)- is a chiral amine derivative of biphenyl, characterized by its specific stereochemistry at the alpha carbon. This compound is a valuable chiral building block and intermediate in the synthesis of complex organic molecules, particularly in the pharmaceutical sector. It is essential for research and development chemists and process engineers working in pharmaceuticals and fine chemical manufacturing who require high-purity, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Intermediate in the development of enantiomerically pure pesticides and herbicides.
• Material Science: Potential monomer or precursor for chiral polymers and advanced organic materials.
• Academic & Industrial R&D: Serves as a reference standard and starting material for novel synthetic methodologies in organic chemistry.

Basic Information

Product Name	[1,1'-Biphenyl]-4-Methanamine, .Alpha.-Methyl-, (.Alpha.R)-
CAS No.	223418-62-0
Molecular Formula	C14H15N
Molecular Weight	197.28 g/mol
Synonyms	(R)-1-(4-Biphenylyl)ethylamine; (αR)-α-Methyl[1,1'-biphenyl]-4-methanamine; (R)-1-([1,1'-Biphenyl]-4-yl)ethanamine; (R)-1-(Biphenyl-4-yl)ethylamine; (R)-4-(1-Aminoethyl)biphenyl; (R)-α-Methyl-4-biphenylmethanamine; (R)-1-(4-Phenylphenyl)ethylamine
EINECS	Contact for details

Quality Control

Our production of [1,1'-Biphenyl]-4-Methanamine, .Alpha.-Methyl-, (.Alpha.R)- adheres to stringent quality protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.