Description

(S)-1-[(R)-2-(Diphenylphosphino)Ferrocenyl]-Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create complex, optically pure molecular architectures.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators where biological activity is often enantiomer-specific.
• Fine Chemical and Specialty Material Production: Facilitates the creation of chiral ligands, catalysts, and advanced materials for electronics and nanotechnology.
• Academic and Industrial R&D: A vital tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Product Name	(S)-1-[(R)-2-(Diphenylphosphino)Ferrocenyl]-Ethyldi(3,5-Xylyl)Phosphine
CAS No.	223121-07-1
Molecular Formula	C49H46FeP2
Molecular Weight	744.68 g/mol
Synonyms	(S,R)-Josiphos SL-J009-1; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos ligand SL-J009-1; (S)-1-[(R)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine (common misnomer); (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethylbis(3,5-dimethylphenyl)phosphine; SL-J009-1; Ferrocenyl Josiphos ligand; Chiral ferrocenyl diphosphine.
EINECS	Contact for details

Quality Control

Our production of (S)-1-[(R)-2-(Diphenylphosphino)Ferrocenyl]-Ethyldi(3,5-Xylyl)Phosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. Each lot is characterized by NMR (1H, 31P), HPLC, and elemental analysis to confirm identity, enantiomeric excess (>99% ee typical), and chemical purity (>97% typical). Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Molecular Formula Confirmation	C49H46FeP2
Residual Solvents (GC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.