Description

(R)-1-[(S)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethyldiphenylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and catalytic activity in a range of transition-metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and alcohols.
• Critical component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) to construct chiral biaryl and C-N bond frameworks.
• Catalyst modifier for enantioselective allylic substitution and isomerization reactions.
• Use in the pharmaceutical development of chiral drug candidates, including APIs and key synthetic intermediates.
• Production of agrochemicals such as herbicides and fungicides with specific stereochemistry for enhanced efficacy.
• Research and development of novel homogeneous catalysts in academic and industrial laboratories.
• Process development and scale-up synthesis of fine chemicals and specialty materials requiring high enantiomeric purity.

Basic Information

Item	Details
Product Name	(R)-1-[(S)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethyldiphenylphosphine
CAS No.	223120-71-6
Molecular Formula	C34H42FeP2
Molecular Weight	568.48 g/mol
Synonyms	(R)-(S)-Josiphos; (R)-1-[(S)-2-(Bis(1,1-dimethylethyl)phosphino)ferrocenyl]ethyldiphenylphosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldiphenylphosphine; (R)-1-[(S)-2-(Di-tert-butylphosphanyl)ferrocenyl]ethyldiphenylphosphane; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyl(diphenyl)phosphine; SL-J009-1; Josiphos Ligand J009-1
EINECS	Contact for details

Quality Control

Our production of (R)-1-[(S)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethyldiphenylphosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for reproducible catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and identity confirmation. We operate under a cGMP-compliant quality management system, and our facilities are designed to prevent cross-contamination, ensuring the material meets the exacting standards required for pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.