Description

Alefacept is a recombinant, dimeric fusion protein designed to modulate T-cell mediated immune responses. This targeted biologic agent is of significant interest for its specific mechanism of action in autoimmune and inflammatory conditions. It is primarily utilized in advanced pharmaceutical research and development for novel therapeutic applications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of biologic drugs targeting specific immune pathways.
• Immunology Research: A critical tool for studying T-cell activation, proliferation, and the CD2 signaling pathway in vitro.
• Autoimmune Disease R&D: Investigational use in the development of novel therapies for conditions mediated by pathogenic T-cells.
• Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control testing in biopharmaceutical manufacturing.
• Biologics Formulation Studies: Used in pre-formulation and stability studies to develop stable and efficacious drug products.

Basic Information

Product Name	Alefacept
CAS No.	222535-22-0
Molecular Formula	C₁₉₉₂H₃₀₆₈N₅₂₂O₆₀₀S₁₆
Molecular Weight	~91.4 kDa
Synonyms	Amevive; LFA-3/IgG1 Fusion Protein; Recombinant LFA-3/IgG1 Fc Fusion Protein; CD2-IgG1 Fusion Protein; BG9273; BG 9273; LFA3TIP; Alefacept (rDNA Origin); Human LFA-3 Fc Fusion Protein
EINECS	Contact for details

Quality Control

Our Alefacept is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting stringent specifications for research and pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE & SEC-HPLC)	≥ 95.0%
Monomer Content (SEC-HPLC)	≥ 90.0%
Protein Content (UV Absorbance)	90.0% - 110.0% of label claim
Biological Activity (Cell-based Assay)	Within specified range
Endotoxin (LAL Test)	< 1.0 EU/mg
Residual Moisture (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.