Description

42-(2-Tetrazolyl)Rapamycin is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin (sirolimus). This compound is of significant interest in pharmaceutical research and development due to its potential for enhanced solubility, bioavailability, or targeted activity compared to the parent molecule. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers developing next-generation therapeutics in oncology, immunology, and anti-aging research.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel rapamycin analogs and prodrugs.
• Immunosuppressant Research: Investigation of modified mTOR pathway inhibitors for organ transplantation and autoimmune diseases.
• Oncology Drug Discovery: Development of targeted cancer therapies that inhibit tumor cell proliferation and angiogenesis.
• Life Science Research: A crucial tool compound for studying cellular processes like autophagy, senescence, and metabolism.
• API Development: Serves as an Active Pharmaceutical Ingredient in the formulation of preclinical and clinical trial materials.
• Bioconjugation Studies: The tetrazole moiety offers a handle for further chemical modification and linker attachment for antibody-drug conjugates (ADCs).

Basic Information

Product Name	42-(2-Tetrazolyl)Rapamycin
CAS No.	221877-56-1
Molecular Formula	C56H83N5O14
Molecular Weight	1050.30 g/mol
Synonyms	42-(2H-Tetrazol-5-yl)rapamycin; 42-(1H-Tetrazol-5-yl)rapamycin; 42-(2-Tetrazolyl)sirolimus; Tetrazolylrapamycin; Rapamycin, 42-(2-tetrazolyl)-; mTOR inhibitor derivative; AZD-8055 analog (related research compound)
EINECS	Contact for details

Quality Control

Our 42-(2-Tetrazolyl)Rapamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.