Description

Fandosentan CAS NO 221241-63-0 is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel treatments for cardiovascular and renal diseases.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery programs.
• Cardiovascular Disease Studies: Used in preclinical research to investigate the role of endothelin receptors in conditions like pulmonary arterial hypertension and heart failure.
• Renal Pharmacology: Employed in studies exploring endothelin-mediated pathways in kidney function and chronic kidney disease.
• Biochemical Assay Development: Acts as a selective ligand in the development of high-throughput screening assays for ETA receptor activity.
• Metabolic Pathway Analysis: Utilized in research to understand the compound's pharmacokinetics and metabolic fate.
• Academic Research: Supplied to universities and laboratories for fundamental pharmacological and physiological studies.

Basic Information

Item	Details
Product Name	Fandosentan
CAS No.	221241-63-0
Molecular Formula	C23H28N4O5S
Molecular Weight	472.56 g/mol
Synonyms	Fandosentan; LU 135252; LU-135252; 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide; N-[5-(Dimethylamino)-1-naphthyl]sulfonyl-3,4-dimethyl-5-isoxazolecarboxamide; 3,4-Dimethyl-5-({[5-(dimethylamino)-1-naphthyl]sulfonyl}carbamoyl)isoxazole
EINECS	Contact for details

Quality Control

Our Fandosentan is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) documenting full compliance with specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.