Description

(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Diphenylphosphino)-3,3'-Bipyridine CAS NO 221012-82-4 is a high-value, chiral bidentate phosphine ligand designed for advanced asymmetric catalysis. This compound matters because it provides exceptional stereoselectivity and catalytic efficiency in complex synthetic transformations, enabling the production of high-purity enantiomerically enriched intermediates. It is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and optimizing synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic synthesis of chiral building blocks for active pharmaceutical ingredients (APIs), including those for cardiovascular and central nervous system drugs.
• Cross-Coupling Reactions: Facilitates asymmetric cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high enantiomeric excess.
• Agrochemical Production: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.
• Fine Chemical Manufacturing: Enables the production of specialty flavors, fragrances, and advanced materials with precise stereochemistry.

Basic Information

Product Name	(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Diphenylphosphino)-3,3'-Bipyridine
CAS No.	221012-82-4
Molecular Formula	C42H38N2O4P2
Molecular Weight	696.71 g/mol
Synonyms	(R)-(+)-DTMBP; (R)-DTMBP; (R)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine; (R)-MeO-BIPHEP derivative; (R)-Tetramethoxy-BIPHEP; (R)-TMBP; (R)-Bisphosphine ligand; (R)-Axially chiral bipyridine phosphine ligand
EINECS	Contact for details

Quality Control

Our (R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Diphenylphosphino)-3,3'-Bipyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and 31P NMR, to ensure high chemical and enantiomeric purity suitable for sensitive catalytic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.