Description

(R)-2-Methyl-N-(Pyridin-3-ylmethylene)propane-2-sulfinamide is a high-purity chiral sulfinamide compound that serves as a critical building block in asymmetric synthesis. Its primary value lies in its role as a versatile chiral auxiliary and ligand for the stereoselective construction of complex molecules, ensuring high enantiomeric purity in final products. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals where precise stereochemistry is paramount.

Application

• As a chiral auxiliary in the asymmetric synthesis of amines and amino acid derivatives.
• Utilized as a ligand or catalyst precursor in transition metal-catalyzed reactions for enantioselective transformations.
• Key intermediate in the research and development of pharmaceutical candidates, especially for central nervous system (CNS) and oncology targets.
• Building block for the synthesis of agrochemicals requiring specific stereochemistry for enhanced biological activity.
• Used in academic and industrial R&D for methodology development in organic and medicinal chemistry.
• Component in the production of fine chemicals and advanced materials where chiral purity is critical.

Basic Information

Item	Details
Product Name	(R)-2-Methyl-N-(Pyridin-3-ylmethylene)propane-2-sulfinamide
CAS No.	220315-22-0
Molecular Formula	C10H14N2OS
Molecular Weight	210.30 g/mol
Synonyms	(R)-2-Methyl-2-propanesulfinamide, N-(3-Pyridinylmethylene)-; (R)-N-(Pyridin-3-ylmethylene)-2-methylpropane-2-sulfinamide; (R)-tert-Butanesulfinamide, N-(3-pyridinylmethylene)-; (R)-2-Methyl-N-(3-pyridylmethylene)propane-2-sulfinamide; (R)-N-[(Pyridin-3-yl)methylidene]-2-methylpropane-2-sulfinamide; (R)-N-(3-Pyridinecarboxaldehyde) tert-Butanesulfinimine; (R)-tert-Butylsulfinyl Imine of 3-Pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our (R)-2-Methyl-N-(Pyridin-3-ylmethylene)propane-2-sulfinamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.