Description

(R)-n-[(1E)-Ethylidene]-2-Methylpropane-2-Sulfinamide CAS NO 220315-18-4 is a high-purity chiral sulfinamide building block, specifically the (R)-enantiomer of the Ellman's sulfinimine derived from pivalaldehyde. This compound matters as a critical chiral auxiliary and ligand in asymmetric synthesis, enabling the stereoselective construction of complex molecules with high enantiomeric purity. It is essential for pharmaceutical R&D chemists and fine chemical manufacturers engaged in producing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials where precise stereochemistry is paramount.

Application

• Asymmetric Synthesis: Serves as a versatile chiral auxiliary in the stereoselective addition of nucleophiles to N-sulfinyl imines for the synthesis of chiral amines, amino acids, and amino alcohols.
• Pharmaceutical Intermediates: A key building block in the research and development of enantiomerically pure APIs, particularly for central nervous system (CNS) drugs and antiviral agents.
• Catalyst & Ligand Preparation: Used in the synthesis of chiral sulfinamide-based ligands for transition metal catalysis.
• Agrochemical Synthesis: Employed in the production of chiral active ingredients for herbicides and fungicides.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic synthesis and scale-up process optimization.
• Material Science: Potential precursor for chiral polymers or frameworks with specific optical properties.

Basic Information

Product Name	(R)-n-[(1E)-Ethylidene]-2-Methylpropane-2-Sulfinamide
CAS No.	220315-18-4
Molecular Formula	C7H15NOS
Molecular Weight	161.26 g/mol
Synonyms	(R)-2-Methyl-N-[(1E)-1-propen-1-yl]-2-propanesulfinamide; (R)-N-[(1E)-1-Propenyl]-2,2-dimethylpropane-2-sulfinamide; (R)-N-[(E)-Ethylidene]-2-methylpropane-2-sulfinamide; (R)-N-(1-Propenyl)-2-methyl-2-propanesulfinamide; (R)-tert-Butanesulfinamide N-(1-propenyl) derivative; (R)-Ellman's Sulfinimine (pivalaldehyde derived); (R)-N-(E)-1-Propenyl-tert-butanesulfinamide; Chiral Sulfinimine Auxiliary
EINECS	Contact for details

Quality Control

Our (R)-n-[(1E)-Ethylidene]-2-Methylpropane-2-Sulfinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.