Description

Methyl 2-Fluoro-4-(Trifluoromethyl)Benzoate is a high-value fluorinated aromatic ester building block. This compound is critical for introducing both fluorine and trifluoromethyl substituents into complex molecular architectures, significantly altering physicochemical properties like lipophilicity and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients. Its specific structure makes it an essential intermediate for creating advanced materials and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where fluorination enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions and esterification processes for introducing benzoate motifs.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new fluorination methodologies and creating compound libraries.

Basic Information

Product Name	Methyl 2-Fluoro-4-(Trifluoromethyl)Benzoate
CAS No.	220162-64-1
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-Fluoro-4-(trifluoromethyl)benzoic acid methyl ester; Methyl 2-fluoro-α,α,α-trifluoro-p-toluate; Benzoic acid, 2-fluoro-4-(trifluoromethyl)-, methyl ester; Methyl 2-fluoro-4-trifluoromethylbenzoate; 2-Fluoro-4-trifluoromethylbenzoic acid methyl ester; Methyl α,α,α,2-tetrafluoro-p-toluate
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Fluoro-4-(Trifluoromethyl)Benzoate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.