Description

(R)-Citalopram Oxalate is the oxalate salt of the single enantiomer of the widely used selective serotonin reuptake inhibitor (SSRI), citalopram. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced chemical synthesis facilities focusing on neuropharmacology and enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control testing of citalopram-based drug products.
• Chiral Intermediate in API Synthesis: Used as a key building block in the research-scale synthesis of enantiomerically pure (R)-citalopram and its derivatives.
• Pharmacological Research: Essential for in-vitro and in-vivo studies investigating the specific biological activity, metabolism, and receptor binding profile of the (R)-enantiomer.
• Impurity Profiling: Employed to identify, quantify, and qualify the (R)-enantiomer as a potential impurity in (S)-citalopram (escitalopram) drug substances and products.
• Process Development & Optimization: Aids in the development and scaling of asymmetric synthesis and chiral separation processes within pharmaceutical manufacturing.

Basic Information

Product Name	(R)-Citalopram Oxalate
CAS No.	219861-53-7
Molecular Formula	C₂₀H₂₁FN₂O • C₂H₂O₄
Molecular Weight	448.46 g/mol
Synonyms	(R)-Citalopram hydrogen oxalate; (R)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile oxalate; (R)-Citalopram oxalic acid salt; (R)-Lu 10-171 oxalate; (R)-Nitalapram oxalate
EINECS	Contact for details

Quality Control

Our (R)-Citalopram Oxalate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.