Description

4-n-Boc-Amino-3-Fluorophenylboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critically important for the development of novel active pharmaceutical ingredients (APIs) and complex molecules, particularly in medicinal chemistry and drug discovery. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical companies engaged in the synthesis of protease inhibitors, kinase inhibitors, and other targeted therapeutics.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to introduce the fluorinated phenylboronic acid moiety into complex molecular architectures.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, especially those targeting cancer and central nervous system (CNS) disorders.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, a major class of antiviral and anticancer agents.
• Kinase Inhibitor Synthesis: Integral to creating kinase inhibitor scaffolds for targeted cancer therapies.
• Peptidomimetics and Bioactive Molecules: Employed in constructing peptidomimetic structures and other molecules designed to modulate biological pathways.
• Agrochemical Research: Can be utilized in the development of new agrochemicals with enhanced efficacy and selectivity.
• Material Science: Potential use as a monomer or precursor in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Item	Detail
Product Name	4-n-Boc-Amino-3-Fluorophenylboronic Acid
CAS No.	218301-87-2
Molecular Formula	C11H15BFNO4
Molecular Weight	255.05 g/mol
Synonyms	4-(tert-Butoxycarbonylamino)-3-fluorobenzeneboronic acid; 3-Fluoro-4-[(tert-butoxycarbonyl)amino]benzeneboronic acid; 4-Boc-amino-3-fluorophenylboronic acid; N-Boc-3-fluoro-4-boronobenzamide; 3-Fluoro-4-[(2-methylpropan-2-yl)oxycarbonylamino]benzeneboronic acid; 4-(Boc-amino)-3-fluorophenylboronic acid; tert-Butyl (3-fluoro-4-boronophenyl)carbamate
EINECS	Contact for details

Quality Control

Our 4-n-Boc-Amino-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.